Intracellular conformations of human telomeric quadruplexes studied by electron paramagnetic resonance spectroscopy.
نویسندگان
چکیده
In-cell DEER (in-cell double electron electron resonance) is applied to investigate quadruplex formation of the human telomeric repeat d[AGGG(TTAGGG)(3)]. The initially unfolded DNA sequence forms a mixture of different quadruplex topologies upon injection into living cells. In addition, time-dependent distance measurements are carried out to monitor quadruplex folding.
منابع مشابه
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عنوان ژورنال:
- Chemphyschem : a European journal of chemical physics and physical chemistry
دوره 13 6 شماره
صفحات -
تاریخ انتشار 2012